"Vitamin K1 (phylloquinone) is found in green leafy plants and is best known for the role it plays in blood clotting. Vitamin K2 (menaquinones) comes in several forms, the most common of which are MK-4, found in animal foods, and MK-7, found in fermented foods. Vitamin K2 plays important roles in bone and cardiovascular health
Research has found that people with the highest intakes of both types of vitamin K have significantly lower risks of atherosclerosis-related heart disease. Those with the highest intakes of vitamin K1 had a 21% lower risk of being hospitalized with atherosclerosis-related heart disease and those with the highest intakes of vitamin K2 had a 14% lower risk. Those with high vitamin K2 intake also had a 34% lower risk of peripheral artery disease
One of the primary ways in which vitamin K2 protects your cardiovascular health is by activating matrix Gla protein (MGP), which is a potent inhibitor of arterial calcification. Vitamin K2 can have a direct blood pressure lowering effect in some individuals
Low vitamin K status also raises the risk of frailty, impaired mobility and disability in elderly individuals
Statin drugs can deplete your body of vitamin K2 by inhibiting MK-4 synthesis. As a consequence, statins may contribute not only to age-related frailty but also insulin resistance, because MK-4 synthesis requires the same enzymes that synthesize cholesterol." JM MD
Sources and References
1 Medicine 2017;96(17): e6725
2, 9 Nutraceutical Business Review, February 23, 2016
3 Osteoporosis International 2013, DOI: 10.1007/s00198-013-2325-4
4, 23 Journal of Agricultural and Food Chemistry 2006; 54: 483-468 (PDF)
5, 7, 24, 25 Haemostasis, 2000; 30: 298
6 Journal of Hepatology, 2007; 47(1): 83
8 Journal of Food Science and Technology 2015 Aug; 52(8): 5212
10, 11 SciTechDaily, January 4, 2022
12 Journal of the American Heart Association March 22, 2019; DOI: 10.1161/JAHA.119.011960
14 Open Heart 2021;8:e001715
15 American Journal of Health-System Pharmacy August 2012; 69(15): 1307-1309
16 Science News June 14, 2019
17 Journals of Gerontology: Series A April 2020; 75(4): 792-797
18 Haidut.me June 6, 2020
19 Journal of the Endocrine Society August 2020; 4(8): bvaa057
20 Healio June 5, 2020
21 Cardiology 2020; 145(6): 384-386
22 Harvard Vitamin K
26 GrassrootsHealth Magnesium and Vitamin K2 Combined Important for Vitamin D Levels
27 YouTube, December 11, 2021 Min 11:13
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