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Avoiding the Pitfalls of Male Aging


As men age they experience unique to them, sexual, hormonal and prostate challenges.

Several nutrients have been shown in studies to raise testosterone levels, improve mood and strength, reduce urinary problems, support prostate health and improve erectile dysfunction.

These nutrients are: an extract of kaempferi parviflora, a combination of pomegranate and cacao seed extracts, saw palmetto, boron and rosemary.

References

  1. Kaufman JM, Lapauw B, Mahmoud A, et al. Aging and the Male Reproductive System. Endocr Rev.2019Aug 1;40(4):906-72.

  2. Stein RA, Schmid K, Bolivar J, et al. Kaempferia parviflora ethanol extract improves self-assessed sexual health in men: a pilot study.J Integr Med.2018Jul;16(4):249-54.

  3. Pandit SL, Yaligar D, Halemane M, et al. A proprietary blend of standardized Punica granatum fruit rind and Theobroma cocoa seed extracts mitigates aging males' symptoms: A randomized, double-blind, placebo-controlled study. Int J Med Sci.2022;19(8):1290-9.

  4. Wilt TJ, Ishani A, Rutks I, et al. Phytotherapy for benign prostatic hyperplasia. Public Health Nutr.2000Dec;3(4A):459-72.

  5. Csikós E, Horváth A, Ács K, et al. Treatment of Benign Prostatic Hyperplasia by Natural Drugs. Molecules.2021Nov 25;26(23).

  6. Available at:https://www.health.harvard.edu/mens-health/which-drug-for-erectile-dysfunction . Accessed May, 11, 2023.

  7. Saokaew S, Wilairat P, Raktanyakan P, et al. Clinical Effects of Krachaidum ( Kaempferia parviflora): A Systematic Review. J Evid Based Complementary Altern Med.2017Jul;22(3):413-28.

  8. Wattanathorn J, Pangphukiew P, Muchimapura S, et al. Aphrodisiac Activity of Kaempferia parviflora.American Journal of Agricultural and Biological Sciences.2012;7(2):114-20.

  9. Chaturapanich G, Chaiyakul S, Verawatnapakul V, et al. Effects of Kaempferia parviflora extracts on reproductive parameters and spermatic blood flow in male rats. Reproduction.2008Oct;136(4):515-22.

  10. Temkitthawon P, Hinds TR, Beavo JA, et al. Kaempferia parviflora, a plant used in traditional medicine to enhance sexual performance contains large amounts of low affinity PDE5 inhibitors. J Ethnopharmacol.2011Oct 11;137(3):1437-41.

  11. Tep-Areenan P, Sawasdee P, Randall M. Possible mechanisms of vasorelaxation for 5,7-dimethoxyflavone from Kaempferia parviflora in the rat aorta. Phytother Res.2010Oct;24(10):1520-5.

  12. Chen D, Li H, Li W, et al. Kaempferia parviflora and Its Methoxyflavones: Chemistry and Biological Activities. Evid Based Complement Alternat Med.2018;2018:4057456.

  13. Wannanon P, Wattanathorn J, Tong-Un T, et al. Efficacy assessment of Kaempferia parviflora for the management of erectile dysfunction. OnLine J. of Biological Sciences.2012;12(4):149-55.

  14. Nam YS, Lee G, Yun JM, et al. Testosterone Replacement, Muscle Strength, and Physical Function. World J Mens Health.2018May;36(2):110-22.

  15. Kelly DM, Jones TH. Testosterone: a metabolic hormone in health and disease. Journal of Endocrinology.201301 Jun. 2013;217(3):R25-R45.

  16. Muehlenbein MP, Gassen J, Shattuck EC, et al. Lower testosterone levels are associated with higher risk of death in men.Evol Med Public Health.2023;11(1):30-40.

  17. Araujo AB, Dixon JM, Suarez EA, et al. Clinical review: Endogenous testosterone and mortality in men: a systematic review and meta-analysis. J Clin Endocrinol Metab.2011Oct;96(10):3007-19.

  18. Nutraceutical L. Internal Study. A randomized, double blind, placebo controlled study to evaluate the efficacy and safety of a novel herbal composition improving aging males’ symptoms. Data on file. 2018.

  19. Heinemann LA, Saad F, Zimmermann T, et al. The Aging Males' Symptoms (AMS) scale: update and compilation of international versions. Health Qual Life Outcomes.2003May 1;1:15.

  20. Sreeramaneni PGA, Yalamanchi A, Konda MR, et al. A Proprietary Herbal Blend Containing Extracts of Punica granatum Fruit Rind and Theobroma cocoa Seeds Increases Serum Testosterone Level in Healthy Young Males: A Randomized, Double-Blind Placebo-Controlled Study. J Diet Suppl.2023;20(3):411-27.

  21. Li F, Wong TY, Lin SM, et al. Coadministrating luteolin minimizes the side effects of the aromatase inhibitor letrozole. J Pharmacol Exp Ther.2014Nov;351(2):270-7.

  22. Lu DF, Yang LJ, Wang F, et al. Inhibitory effect of luteolin on estrogen biosynthesis in human ovarian granulosa cells by suppression of aromatase (CYP19). J Agric Food Chem.2012Aug 29;60(34):8411-8.

  23. Couture R, Mora N, Al Bittar S, et al. Luteolin modulates gene expression related to steroidogenesis, apoptosis, and stress response in rat LC540 tumor Leydig cells. Cell Biol Toxicol.2020Feb;36(1):31-49.

  24. Hizli F, Uygur MC. A prospective study of the efficacy of Serenoa repens, tamsulosin, and Serenoa repens plus tamsulosin treatment for patients with benign prostate hyperplasia. Int Urol Nephrol.2007;39(3):879-86.

  25. Available at:https://www.nccih.nih.gov/health/providers/digest/spotlight-on-saw-palmetto-science . Accessed May, 12, 2023.

  26. Sudeep HV, Thomas JV, Shyamprasad K. A double blind, placebo-controlled randomized comparative study on the efficacy of phytosterol-enriched and conventional saw palmetto oil in mitigating benign prostate hyperplasia and androgen deficiency. BMC Urology.20202020/07/03;20(1):86.

  27. Kwon Y. Use of saw palmetto (Serenoa repens) extract for benign prostatic hyperplasia. Food Sci Biotechnol.2019Dec;28(6):1599-606.

  28. Ishii I, Wada T, Takara T. Effects of saw palmetto fruit extract intake on improving urination issues in Japanese men: A randomized, double-blind, parallel-group, placebo-controlled study. Food Sci Nutr. 2020Aug;8(8):4017-26.

  29. Barry MJ, Meleth S, Lee JY, et al. Effect of Increasing Doses of Saw Palmetto Extract on Lower Urinary Tract Symptoms: A Randomized Trial. JAMA.2011;306(12):1344-51.

  30. Zamani P, Mokhtari O, Dehghanian F. Identification of Beta-Sitosterol and Stigmasterol as Possible Inhibitors of 5 Alpha-Reductase 1: An In-Silico Study. Precision Medicine and Clinical OMICS.2022;1(1):e121545.

  31. Available at: https://www.herbalgram.org/resources/herbalgram/issues/72/table-of-contents/article3033/ . Accessed May, 12, 2023.

  32. Safarinejad MR. Urtica dioica for treatment of benign prostatic hyperplasia: a prospective, randomized, double-blind, placebo-controlled, crossover study. J Herb Pharmacother.2005;5(4):1-11.

  33. Pizzorno L. Nothing Boring About Boron. Integr Med (Encinitas).2015Aug;14(4):35-48.

  34. Petiwala SM, Puthenveetil AG, Johnson JJ. Polyphenols from the Mediterranean herb rosemary (Rosmarinus officinalis) for prostate cancer. Front Pharmacol.2013;4:29.

  35. Jaglanian A, Termini D, Tsiani E. Rosemary (Rosmarinus officinalis L.) extract inhibits prostate cancer cell proliferation and survival by targeting Akt and mTOR. Biomed Pharmacother.2020Nov;131:110717.


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